N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester

Base Information

Chemical Name:N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester
CAS No.:129575-01-5
Molecular Formula:C₃₃H₅₄N₄O₁₀Si
Molecular Weight:694.898
Hs Code.:

N-<1-<N-(1,1-dimethylethoxy)carbonyl>glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester

Synonyms:N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester

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Chemical Property of N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester

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Technology Process of N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester

There total 3 articles about N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

: 129575-00-4
N-<1-glycyl>-trans-3-<4-(1-hydroxy-2-nitroethyl)phenoxy>-L-prolyl-L-isoleucine methyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 129575-01-5
N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; 1.) 0 deg C, 30 min, 2.) RT, 9.5 h;

Reference yield:

: 129574-99-8
N-<1-glycyl>-trans-3-<4-(formylphenoxy)-L-prolyl>-L-isoleucine methyl ester

: 129575-01-5
N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93.6 percent / sodium methoxide / 3.5 h / 0 °C

2: 94.8 percent / imidazole / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 9.5 h

With 1H-imidazole; sodium methylate; In N,N-dimethyl-formamide;

Reference yield:

: 123043-38-9,123043-39-0
N-trans-3-(4-cyanophenoxy)-1-glycyl>-L-prolyl-L-isoleucine methyl ester

: 129575-01-5
N-<1-glycyl>-trans-3-<4-(1,1-dimethylethyl)dimethylsilyloxy>-2-(nitroethyl)phenoxy-L-prolyl-L-isoleucine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76.4 percent / Raney Ni, NaH₂PO₂*H₂O, buffer 2:1:1 pyridine: acetic acid: water / 4 h / 55 - 60 °C

2: 93.6 percent / sodium methoxide / 3.5 h / 0 °C

3: 94.8 percent / imidazole / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 9.5 h

With 1H-imidazole; sodium hypophosphite; buffer 2:1:1 pyridine: acetic acid: water; sodium methylate; nickel; isobutyric Acid; In N,N-dimethyl-formamide;