3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Base Information

Chemical Name:3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide
CAS No.:1432514-77-6
Molecular Formula:C₃₁H₂₉FN₄O₈S₂
Molecular Weight:668.724
Hs Code.:

3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Synonyms:3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

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Chemical Property of 3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

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Technology Process of 3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

There total 9 articles about 3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432514-76-5
(3',4-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methanol

: 1432514-64-1
N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

: 1432514-77-6
3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Guidance literature:: With di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; at 18 - 25 ℃; for 16h;

Reference yield:

: 134465-87-5
8'-bromo-3',4'-dihydrospiro-<1,3-dioxolane-2,2'(1H)-naphthalene>

: 1432514-77-6
3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / dimethyl sulfoxide / 16 h / 80 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

3: di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 18 - 25 °C

With di-tert-butyl-diazodicarboxylate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 117294-21-0
8-bromo-2-tetralone

: 1432514-77-6
3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 125 °C

2: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / dimethyl sulfoxide / 16 h / 80 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

4: di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 18 - 25 °C

With di-tert-butyl-diazodicarboxylate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; toluene;