117294-21-0

Basic information

• Product Name: 8-Bromo-2-tetralone
• Synonyms: 8-BROMO-2-TETRALONE;8-BROMO-3,4-DIHYDRO-1H-NAPHTHALEN-2-ONE;8B2T;8-broMo-3;8-BroMo-1,2,3,4-tetrahydro-2-oxonaphthalene;8-Bromotetralin-2-one
• CAS NO: 117294-21-0
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.08
• Product Categories: api
• Mol File: 117294-21-0.mol

Chemical Properties

• Boiling Point: 330.977 °C at 760 mmHg
• Flash Point: 117.027 °C
• Appearance: /
• Density: 1.511 g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-Bromo-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Bromo-2-tetralone(117294-21-0)
• EPA Substance Registry System: 8-Bromo-2-tetralone(117294-21-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 117294-21-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
8-Bromo-2-tetralone is used as a precursor or intermediate for the synthesis of various chemical compounds, contributing to the development of new materials and products in the field of organic chemistry.
Used in Pharmaceutical Industry:
8-Bromo-2-tetralone is used as a key intermediate in the production of certain pharmaceuticals, facilitating the creation of new drugs and therapeutic agents.
Used in Research and Development:
8-Bromo-2-tetralone is employed as a research compound in academic and industrial laboratories, aiding in the exploration of new chemical reactions and the discovery of novel chemical entities.
Used in Material Science:
8-Bromo-2-tetralone is used as a component in the development of new materials, such as polymers and composites, with potential applications in various industries.

InChI:InChI=1/C10H9BrO/c11-10-3-1-2-7-4-5-8(12)6-9(7)10/h1-3H,4-6H2

Upstream product

• 18698-97-0 ortho-bromophenylacetic acid 
• 55116-09-1 2-bromophenylacetyl chloride 
• 74-85-1 ethene 

Downstream Products

• 136924-89-5 (+)-(2R)-8-bromo-N-<(S)-α-methylbenzyl>-2-aminotetralin 
• 136924-90-8 (-)-(2S)-8-bromo-N-<(S)-α-methylbenzyl>-2-aminotetralin 
• 214746-44-8 methyl 4-[(8-bromo-3,4-dihydro-2-naphthalenyl)methyl]benzoate 
• 444619-84-5 8-bromo-1,2,3,4-tetrahydronaphthalen-2-ol 
• 444619-84-5 (R)-8-bromo-1,2,3,4-tetrahydronaphthalene-2-ol 
• 624729-66-4 8-amino-1,2,3,4-tetrahydronaphthalen-2-ol 
• 161661-18-3 2-amino-8-bromotetraline 
• 35387-22-5 7-Methyl-[1]naphthoesaeure 
• 1432514-77-6 3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide 
• 1237484-75-1 8-bromo-N-[(S)-alpha-methylbenzyl]-2-aminotetralin 
• 7385-87-7 8-bromo-naphthalene-2-ol 
• 163498-77-9 8-bromo-2-(dibenzylamino)-naphthalene 
• 98331-27-2 8-bromo-2-(bromomethyl)naphthalene 
• 135942-96-0 1-cyano-7-(bromomethyl)naphthalene 

Relevant articles and documents

A new, simple procedure for the preparation of 8-methoxy-2-tetralone

8-Methoxy-2-tetralone (6) can be easily prepared in approximately 50% overall yield starting from 2-bromophenylacetic acid (1), utilizing a Friedel-Crafts acylation/cyclization, ketone protection, copper(I)-catalyzed methoxylation of the aromatic bromide

Novel [(diazomethyl)carbonyl]-1,2,3,4-tetrahydronaphthalene derivatives as potential photoaffinity ligands for the 5-HT(1A) receptor

The photolabile (diazomethyl)carbonyl function was introduced into the 8-position of 2-(N,N-di-n-propyl-amino)-1,2,3,4-tetrahydronaphthalene in three ways, resulting in the ether 8-[[(diazomethyl)carbonyl]methoxy]-2-(N,N-di-n-propylamino)-1,2,3,4-te trahy

The synthesis of (S)-di-n-propyl-(8-isoxazol-5-yl-1,2,3,4- tetrahydronaphthalen-2-yl)amine hydrochloride and its C-14-labeled isotopomer

The partial ergoline LY228729 (1) which was a potent 5HT1A agonist has been studied clinically. Somewhat later, a related analog, (S)-di-n-propyl-(8-isoxazol-5-yl-1,2,3,4-tetrahydronaphthalen-2-yl)amine (2a) which in addition to potent 5HT

Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Histidine substitution

Systematic substitution of His6 residue using non-selective hMC4R pentapeptide agonist (Bu-His6-DPhe7-Arg8-Trp9-Gly 10-NH2) as the template led to the identification of Bu-Atcsu

Antihyperglycemic Activity of Novel Naphthalenyl 3H-1,2,3,5-Oxathiadiazole 2-Oxides

A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus.Substitution at the 1-,5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4--3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.

Novel 2-substituted tetrahydro-3H-benz[e]indolamines: Highly potent and selective agonists acting at the 5-HT(1A) receptor as possible anxiolytics and antidepressants

The synthesis of (+)-(R)-2-cyano-N,N-dipropyl-8-amino-6,7,8,9-tetrahydro- 3H-benz[e]indole [(R)-14, U92016A], a potent 5-HT(1A) agonist, and related analogs is described. In vitro binding studies show that the (R)-enantiomers of this series possess the hi

5-, 6-, 7- and 8-amino-2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydrophthalenes: Centrally acting DA and 5-HT(1A) agonists

5-, 6-, 7- and 8-Amino-2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydronaphthalene were synthesized and compared with the corresponding phenolic compounds in vivo and in vitro for their effects on central serotonergic (5-HT(1A)) and dopaminergic (D2) systems. The 5- and 8-amino isomers surprisingly showed a 100-fold lower affinity for D2 and 5-HT(1A) receptors, respectively, than their corresponding phenols. This was also reflected in vivo. The 6-amino- and hydroxy-isomers were equipotent, while the 7-amino compound showed in vivo effects both on dopaminergic and serotonergic systems, the latter not being noticed in vitro. Intermediates 8-bromo-2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydronaphthalene and 2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydronaphthalene-8-carboxylic acid methyl ester were also tested and found to be quite potent 5-HT(1A) agonists.

Novel naphthalenylalkyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents

This invention relates to novel [(substituted naphthalenyl)alkyl]-3H-1,2,3,5-oxathiadiazole 2-oxides, to the processes for their preparation, to methods for using the compounds, and to pharmaceutical compositions thereof. The compounds have pharmaceutical

Processes for the preparation of novel naphthalenylmethyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents

This invention relates to the processes for the production of novel [(substituted naphthalenyl)methyl]-3H-1,2,3,5-oxathiadiazole 2-oxides. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and

8-Substituted 2-aminotetralins

New 8-substituted 2-aminotetralins can be prepared from the corresponding aminotetralins or tetralones. They can be used in medicaments.