117294-21-0

Basic information

• Product Name: 8-Bromo-2-tetralone
• Synonyms: 8-BROMO-2-TETRALONE;8-BROMO-3,4-DIHYDRO-1H-NAPHTHALEN-2-ONE;8B2T;8-broMo-3;8-BroMo-1,2,3,4-tetrahydro-2-oxonaphthalene;8-Bromotetralin-2-one
• CAS NO: 117294-21-0
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.08
• Product Categories: api
• Mol File: 117294-21-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 330.977 °C at 760 mmHg
• Flash Point: 117.027 °C
• Appearance: /
• Density: 1.511 g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-Bromo-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Bromo-2-tetralone(117294-21-0)
• EPA Substance Registry System: 8-Bromo-2-tetralone(117294-21-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 117294-21-0(Hazardous Substances Data)

Usage

General Description

8-Bromo-2-tetralone is a chemical compound that is mostly applied in organic chemistry, primarily as a precursor or intermediate substance in the synthesis of other chemical compounds. It displays a strong aromatic scent distinctive to compounds in a ketone group. The exact molecular formula of 8-bromo-2-tetralone is C10H7BrO while its molecular weight is 227.06 g/mol. Its physical properties include a melting point range of 39-41 °C and boiling point range of 241-243°C. It has a stable shelf life under normal temperatures and pressures, and it should be stored in a cool, dry place to maintain its stability. As with all chemical compounds, its handling and usage warrant careful attention to minimize potential health hazards.

InChI:InChI=1/C10H9BrO/c11-10-3-1-2-7-4-5-8(12)6-9(7)10/h1-3H,4-6H2

Upstream product

• 74-85-1 ethene 
• 55116-09-1 2-bromophenylacetyl chloride 
• 18698-97-0 ortho-bromophenylacetic acid 

Downstream Products

• 136924-89-5 (+)-(2R)-8-bromo-N-<(S)-α-methylbenzyl>-2-aminotetralin 
• 136924-90-8 (-)-(2S)-8-bromo-N-<(S)-α-methylbenzyl>-2-aminotetralin 
• 163498-77-9 8-bromo-2-(dibenzylamino)-naphthalene 
• 214746-44-8 methyl 4-[(8-bromo-3,4-dihydro-2-naphthalenyl)methyl]benzoate 
• 1237484-75-1 8-bromo-N-[(S)-alpha-methylbenzyl]-2-aminotetralin 
• 444619-84-5 8-bromo-1,2,3,4-tetrahydronaphthalen-2-ol 
• 444619-84-5 (R)-8-bromo-1,2,3,4-tetrahydronaphthalene-2-ol 
• 624729-66-4 8-amino-1,2,3,4-tetrahydronaphthalen-2-ol 
• 161661-18-3 2-amino-8-bromotetraline 
• 35387-22-5 7-Methyl-[1]naphthoesaeure 
• 1432514-77-6 3-((3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl)methyl)-N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide 
• 7385-87-7 8-bromo-naphthalene-2-ol 
• 98331-27-2 8-bromo-2-(bromomethyl)naphthalene 
• 135942-96-0 1-cyano-7-(bromomethyl)naphthalene 

Relevant articles and documents

A new, simple procedure for the preparation of 8-methoxy-2-tetralone

8-Methoxy-2-tetralone (6) can be easily prepared in approximately 50% overall yield starting from 2-bromophenylacetic acid (1), utilizing a Friedel-Crafts acylation/cyclization, ketone protection, copper(I)-catalyzed methoxylation of the aromatic bromide

The synthesis of (S)-di-n-propyl-(8-isoxazol-5-yl-1,2,3,4- tetrahydronaphthalen-2-yl)amine hydrochloride and its C-14-labeled isotopomer

The partial ergoline LY228729 (1) which was a potent 5HT1A agonist has been studied clinically. Somewhat later, a related analog, (S)-di-n-propyl-(8-isoxazol-5-yl-1,2,3,4-tetrahydronaphthalen-2-yl)amine (2a) which in addition to potent 5HT

Antihyperglycemic Activity of Novel Naphthalenyl 3H-1,2,3,5-Oxathiadiazole 2-Oxides

A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus.Substitution at the 1-,5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4--3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.