(4-(Benzyloxy)-2,5-dimethoxyphenyl)boronic acid

Base Information

Chemical Name:(4-(Benzyloxy)-2,5-dimethoxyphenyl)boronic acid
CAS No.:524713-44-8
Molecular Formula:C₁₅H₁₇BO₅
Molecular Weight:288.108
Hs Code.:
DSSTox Substance ID:DTXSID001215575

Synonyms:4-BENZYLOXY-2,5-DIMETHOXYPHENYLBORONIC ACID;524713-44-8;(4-(benzyloxy)-2,5-dimethoxyphenyl)boronic acid;SCHEMBL1318465;PMKWGZHHUWATRR-UHFFFAOYSA-N;DTXSID001215575;AB29693;B-[2,5-Dimethoxy-4-(phenylmethoxy)phenyl]boronic acid

Suppliers and Price of (4-(Benzyloxy)-2,5-dimethoxyphenyl)boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (4-(Benzyloxy)-2,5-dimethoxyphenyl)boronic acid

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:288.1169038
Heavy Atom Count:21
Complexity:296

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:B(C1=CC(=C(C=C1OC)OCC2=CC=CC=C2)OC)(O)O

Technology Process of (4-(Benzyloxy)-2,5-dimethoxyphenyl)boronic acid

There total 6 articles about (4-(Benzyloxy)-2,5-dimethoxyphenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 524713-43-7
1-benzyloxy-4-bromo-2,5-dimethoxybenzene

: 524713-44-8
4-benzyloxy-2,5-dimethoxyphenylboronic acid

Guidance literature:: 1-benzyloxy-4-bromo-2,5-dimethoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h;

With Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 22h;

Reference yield: 62.0%

: 5419-55-6
Triisopropyl borate

: 524713-43-7
1-benzyloxy-4-bromo-2,5-dimethoxybenzene

: 524713-44-8
4-benzyloxy-2,5-dimethoxyphenylboronic acid

Guidance literature:: 1-benzyloxy-4-bromo-2,5-dimethoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h;

Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 22h;
DOI:10.1021/jm034007d

Reference yield:

: 2973-59-3
2-bromoisovanillin

: 524713-44-8
4-benzyloxy-2,5-dimethoxyphenylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / K₂CO₃ / acetonitrile / 20 h / 50 °C

2.1: 85 percent / mCPBA / CH₂Cl₂ / 14 h / Heating

3.1: NaH / tetrahydrofuran / 0.33 h

3.2: 88 percent / tetrahydrofuran / 18 h / 20 °C

4.1: nBuLi / tetrahydrofuran / 0.33 h / -78 °C

4.2: 62 percent / tetrahydrofuran / 22 h / -78 - 20 °C

With n-butyllithium; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm034007d