2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid

Base Information

Chemical Name:2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid
CAS No.:329326-37-6
Molecular Formula:C₁₉H₂₅N₄O₈P
Molecular Weight:468.403
Hs Code.:

Synonyms:2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid

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Chemical Property of 2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid

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Technology Process of 2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid

There total 4 articles about 2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 329326-36-5
diethyl-(2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethyl)phosphonate

: 329326-37-6
2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid

Guidance literature:: diethyl-(2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethyl)phosphonate; With trimethylsilyl bromide; In dichloromethane; for 7h;

With triethylamine carbonate; for 0.0833333h;

With sodium hydrogencarbonate; benzyl chloroformate; In water;
DOI:10.1016/S0968-0896(00)00230-3

Reference yield:

: 20924-05-4
thymidyl acetic acid

: 329326-37-6
2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / dicyclohexylcarbodiimide / dimethylformamide / 20 °C

2.1: Me₃SiBr / CH₂Cl₂ / 7 h

2.2: aq. triethylammonium bicarbonate / 0.08 h

2.3: 90 percent / benzyl chloroformate; NaHCO₃ / H₂O

With trimethylsilyl bromide; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(00)00230-3

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 329326-37-6
2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: PhCHO; MgSO₄; K₂CO₃ / CHCl₃ / 2 h / 20 °C

1.2: CHCl₃ / 2.5 h / -20 - 20 °C

1.3: 65 percent / aq. HCl / CHCl₃ / 3 h / 20 °C

2.1: 96 percent / dicyclohexylcarbodiimide / dimethylformamide / 20 °C

3.1: Me₃SiBr / CH₂Cl₂ / 7 h

3.2: aq. triethylammonium bicarbonate / 0.08 h

3.3: 90 percent / benzyl chloroformate; NaHCO₃ / H₂O

With trimethylsilyl bromide; magnesium sulfate; potassium carbonate; benzaldehyde; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(00)00230-3