[2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester

Base Information

• Chemical Name: [2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester
• CAS No.: 144912-97-0
• Molecular Formula: C₁₆H₂₇N₂O₅P
• Molecular Weight: 358.375
• Mol file: 144912-97-0.mol

Synonyms:[2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester

Chemical Property of [2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester

There total 5 articles about [2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

benzyl chloroformate (501-53-1,94274-21-2) + 1-diethoxyphosphoryl-2-(β-aminoethyl)aminoethane (144912-80-1) → [2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester (144912-97-0)

Guidance literature:

1-diethoxyphosphoryl-2-(β-aminoethyl)aminoethane; With magnesium sulfate; potassium carbonate; benzaldehyde; In chloroform; at 20 ℃; for 2h;

benzyl chloroformate; In chloroform; at -20 - 20 ℃; for 2.5h;

With hydrogenchloride; In chloroform; at 20 ℃; for 3h;

DOI:10.1016/S0968-0896(00)00230-3

Reference yield: 51.0%

(2-oxoethyl)phosphonic acid diethyl ester (1606-75-3) + 2-benzyloxycarbonylaminoethylamine (72080-83-2) → [2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester (144912-97-0)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride;

DOI:10.1021/jm970504g

Reference yield:

methanolic hydrogen chloride + 2-benzyloxycarbonylaminoethylamine (72080-83-2) → [2-[[2-(diethoxyphosphinyl)ethyl]amino]ethyl]carbamic acid phenylmethyl ester (144912-97-0)

Guidance literature:

With sodium cyanoborohydride; In dichloromethane;

upstream raw materials:

benzyl chloroformate

1-diethoxyphosphoryl-2-(β-aminoethyl)aminoethane

(2-oxoethyl)phosphonic acid diethyl ester

2-benzyloxycarbonylaminoethylamine

Downstream raw materials:

(4-N-benzoyl-3'-O-tert-butyldimethylsilyl)-2'-deoxycytidin-5'-O-yl-(2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethyl)phosphonic acid

2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid