(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate

Base Information

Chemical Name:(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate
CAS No.:1315282-21-3
Molecular Formula:C₂₇H₂₆N₂O₃
Molecular Weight:426.515
Hs Code.:

Synonyms:(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate

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Technology Process of (1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate

There total 3 articles about (1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 15914-84-8,1517-72-2
(S)-1-(1-Naphthyl)ethanol

: 1315282-23-5
(3S)-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyric acid

: 1315282-21-3
(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1002/anie.201102405

Reference yield:

: 1315282-10-0
C₂₄H₂₂N₄O₄

: 1315282-21-3
(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/anie.201102405

Reference yield:

: 99802-91-2
2-cinnamoyl-1-methyl-1H-imidazole

: 1315282-21-3
(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate

Guidance literature:: Multi-step reaction with 3 steps

1: silver hexafluoroantimonate; hexafluoropropan-2-ol; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; copper dichloride / dichloromethane / 72 h / -78 °C / Molecular sieve; Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C / Inert atmosphere

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; silver hexafluoroantimonate; hexafluoropropan-2-ol; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper dichloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; 1: Mukaiyama-Michael reaction;
DOI:10.1002/anie.201102405