(1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate

Base Information

Chemical Name:(1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate
CAS No.:1315282-25-7
Molecular Formula:C₂₄H₂₄O₄
Molecular Weight:376.452
Hs Code.:

Synonyms:(1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate

Chemical Property:

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Technology Process of (1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate

There total 4 articles about (1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 67-56-1
methanol

: 1315282-21-3
(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate

: 1315282-25-7
(1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate

Guidance literature:: (1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate; With methyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 2.5h; Molecular sieve; Inert atmosphere;

methanol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/anie.201102405

Reference yield:

: 1315282-10-0
C₂₄H₂₂N₄O₄

: 1315282-25-7
(1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C / Inert atmosphere

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: methyl trifluoromethanesulfonate / acetonitrile / 2.5 h / 20 °C / Molecular sieve; Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; methyl trifluoromethanesulfonate; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/anie.201102405

Reference yield:

: 1315282-23-5
(3S)-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyric acid

: 1315282-25-7
(1'S,3S)-1-(1'-naphthyl)ethyl methyl 3-phenylpentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: methyl trifluoromethanesulfonate / acetonitrile / 2.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; methyl trifluoromethanesulfonate; In dichloromethane; acetonitrile;
DOI:10.1002/anie.201102405