3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

Base Information

Chemical Name:3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one
CAS No.:1012878-93-1
Molecular Formula:C₁₇H₁₅ClFN₃O
Molecular Weight:331.777
Hs Code.:

Synonyms:3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

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Chemical Property of 3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

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Technology Process of 3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

There total 9 articles about 3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 959163-01-0
6-chloro-4-ethylamino-pyridine-3-carbaldehyde

: 1012880-05-5
ethyl 2-(5-amino-4-fluoro-2-methylphenyl)acetate

: 1012878-93-1
3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: With aluminum oxide; potassium fluoride; In N,N-dimethyl acetamide; for 2h; Sonication;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1012878-93-1
3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

With manganese(IV) oxide; aluminum oxide; potassium fluoride; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 959162-99-3
(6-chloro-4-(ethylamino)pyridin-3-yl)methanol

: 1012878-93-1
3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

With manganese(IV) oxide; aluminum oxide; potassium fluoride; In dichloromethane; N,N-dimethyl acetamide;