(S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol

Base Information

Chemical Name:(S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol
CAS No.:1354046-12-0
Molecular Formula:C₁₉H₁₈F₃NO
Molecular Weight:333.353
Hs Code.:

Synonyms:(S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol

Suppliers and Price of (S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol

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Technology Process of (S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol

There total 2 articles about (S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propanal

: 1354046-12-0
(S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; isopropyl alcohol; for 0.5h;
DOI:10.1016/j.tetlet.2011.11.007

Reference yield:

: 603-76-9
1-methylindole

: 722549-18-0
3-<2-(trifluoromethyl)phenyl>-2-propenal

: 1354046-12-0
(S)-3-(1-methyl-1H-indol-3-yl)-3-(2-(trifluoromethyl)phenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: (S)-5-benzyl-2,2,3-trimethylimidazolidine-4-thione; trifluoroacetic acid / tetrahydrofuran; isopropyl alcohol / 0.25 h / 20 °C

1.2: 48 h / -25 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol; isopropyl alcohol / 0.5 h

With sodium tetrahydroborate; (S)-5-benzyl-2,2,3-trimethylimidazolidine-4-thione; trifluoroacetic acid; In tetrahydrofuran; ethanol; isopropyl alcohol; 1.1: Friedel-Crafts alkylation / 1.2: Friedel-Crafts alkylation;
DOI:10.1016/j.tetlet.2011.11.007