(2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine

Base Information

• Chemical Name: (2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine
• CAS No.: 629957-59-1
• Molecular Formula: C₂₄H₂₄BrF₇N₂O
• Molecular Weight: 569.36

Synonyms:(2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine

Chemical Property of (2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine

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Technology Process of (2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine

There total 1 articles about (2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,4S)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine → (2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine (629957-59-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

(2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine (629957-59-1) + potassium thioacetate (10387-40-3) → (2R,4S)-4-acetylthio-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)piperidine

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 80 ℃; for 2h;

Reference yield:

Thiomorpholin (123-90-0) + (2R,4R)-1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylaminocarbonyl]-4-bromo-2-(4-fluoro-2-methyl-phenyl)piperidine (629957-59-1) → 4-(S)-[1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylamino-carbonyl]-2-(R)-(4-fluoro-2-methylphenyl)piperidin-4-yl]thiomorpholine (928791-15-5)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 16h; Product distribution / selectivity;

Downstream raw materials:

4-(S)-[1-[N-{1-(R)-(3,5-bistrifluoromethylphenyl)-ethyl}-N-methylamino-carbonyl]-2-(R)-(4-fluoro-2-methylphenyl)piperidin-4-yl]thiomorpholine

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