(E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide

Base Information

• Chemical Name: (E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide
• CAS No.: 1613726-88-7
• Molecular Formula: C₁₉H₂₀N₆O₂
• Molecular Weight: 364.407
• Mol file: 1613726-88-7.mol

Synonyms:(E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide

Chemical Property of (E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide

There total 3 articles about (E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

isoniazid (54-85-3,7640-37-1) + 4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde (1613726-67-2) → (E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide (1613726-88-7)

Guidance literature:

In ethanol; water; at 20 ℃;

DOI:10.1016/j.ejmech.2014.05.005

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → (E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide (1613726-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 - 40 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 20 - 40 °C

3: water; ethanol / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2014.05.005

Reference yield:

4-(prop-2-ynyloxy)benzaldehyde (5651-86-5) → (E)-N'-(4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzylidene)isonicotinohydrazide (1613726-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 20 - 40 °C

2: water; ethanol / 20 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In ethanol; water; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2014.05.005

upstream raw materials:

4-(prop-2-ynyloxy)benzaldehyde

4-hydroxy-benzaldehyde

isoniazid

4-((1-propyl-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde