{2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol

Base Information

• Chemical Name: {2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol
• CAS No.: 1007835-68-8
• Molecular Formula: C₂₀H₂₅Cl₂N₃O₂
• Molecular Weight: 410.343
• Mol file: 1007835-68-8.mol

Synonyms:{2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol

Chemical Property of {2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol

There total 6 articles about {2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamine (916342-89-7) + (2,6-dichloropyridin-4-yl)methanol (101990-69-6) → {2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol (1007835-68-8)

Guidance literature:

In N,N-dimethyl-formamide; at 220 ℃; for 1h;

Reference yield:

[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (916344-01-9) → {2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol (1007835-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 2 h / 20 °C

2: N,N-dimethyl-formamide / 1 h / 220 °C

With hydrogenchloride; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

(4-chloro-3-ethoxy-phenyl)methanol → {2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol (1007835-68-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: manganese(IV) oxide / dichloromethane / 16 h

2.1: acetic acid / ethanol / 0.08 h / 100 °C / Microwave irradiation

2.2: 0.17 h / 100 °C / Microwave irradiation

3.1: hydrogenchloride / ethanol; water / 2 h / 20 °C

4.1: N,N-dimethyl-formamide / 1 h / 220 °C

With hydrogenchloride; manganese(IV) oxide; acetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamine

(2,6-dichloropyridin-4-yl)methanol

[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

4-chloro-3-hydroxybenzoic acid