101990-69-6

Basic information

• Product Name: 3,5-BIS(METHYLSULFONYL)ANILINE
• Synonyms: 3,5-BIS(METHYLSULFONYL)ANILINE;3,5-BIS(METHYLSULPHONYL)ANILINE;2,6-DICHLORO-4-PYRIDINYL METHANOL;(2,6-DICHLORO-4-PYRIDYL)METHANOL;2,6-DICHLOROPYRIDINE-4-METHANOL;2,6-Dichloro-4-(hydroxymethyl)pyridine;2,6-Dichloropyridine-4-methanol ,98%;(2,6-dichloropyridin- 4-yl)methanol
• CAS NO: 101990-69-6
• Molecular Formula: C₆H₅Cl₂NO
• Molecular Weight: 178.02
• Product Categories: Heterocycle-Pyridine series
• Mol File: 101990-69-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: /
• Density: 1.478 g/cm³
• Vapor Pressure: 0.000207mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.72±0.10(Predicted)
• CAS DataBase Reference: 3,5-BIS(METHYLSULFONYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(METHYLSULFONYL)ANILINE(101990-69-6)
• EPA Substance Registry System: 3,5-BIS(METHYLSULFONYL)ANILINE(101990-69-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 101990-69-6(Hazardous Substances Data)

Usage

Description

3,5-BIS(METHYLSULFONYL)ANILINE is an organic compound characterized by its white powder form. It is known for its unique chemical properties, which make it a versatile reagent in various chemical reactions and applications.

Uses

Used in Chemical Synthesis:
3,5-BIS(METHYLSULFONYL)ANILINE is used as a reagent for the preparation of functionalized compounds such as bipyridines and terpyridines. This application is facilitated through Stille-type cross coupling, a widely used method in organic chemistry for the formation of carbon-carbon bonds.
Used in Fluorescent Chemosensors:
3,5-BIS(METHYLSULFONYL)ANILINE is also utilized in the development of fluorescent chemosensors. These sensors are essential tools in various fields, including environmental monitoring, medical diagnostics, and chemical analysis, due to their ability to detect and respond to specific target molecules with high sensitivity and selectivity.

InChI:InChI=1/C6H5Cl2NO/c7-5-1-4(3-10)2-6(8)9-5/h1-2,10H,3H2

Upstream product

• 113293-70-2 2,6-dichloropyridine-4-carbaldehyde 
• 309294-81-3 octyl 2,6-dichloro-4-isonicotinate 
• 42521-08-4 2,6-dichloroisonicotinoyl chloride 
• 89281-13-0 2,6-dichloropyridine-4-carboxamide 
• 32710-65-9 2,6-dichloro-4-cyanopyridine 
• 99-11-6 citrazinic acid 
• 42521-09-5 methyl 2,6-dichloroisonicotinate 
• 1604-14-4 2,6-dichloroisonicotinic acid ethyl ester 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 88579-63-9 (2,6-dichloropyridin-4-yl)methanamine 

Downstream Products

• 586-95-8 pyridine-4-methanol 
• 113293-70-2 2,6-dichloropyridine-4-carbaldehyde 
• 1007835-68-8 {2-chloro-6-[1-(4-chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyridin-4-yl}-methanol 
• 211183-10-7 C₂₀H₁₉N₃O₅S₂ 
• 46721-93-1 pyridin-4-ylmethyl benzoate 
• 6457-49-4 4-piperidinemethanol 
• 101990-72-1 2,6-dichloro-pyridin-4-ylmethyl chloride 
• 1270809-02-3 methyl (S)-3-[4-(2,6-dichloropyridin-4-yl-methoxy)benzoylamino]-2-piperidin-1-ylpropanoate 

Relevant articles and documents

Efficient discovery of fluorescent chemosensors based on a biarylpyridine scaffold

(Figure Presented) The discovery of several fluorescent chemosensors for Hg(II) and Ag(I) In mixed aqueous solution Is reported. The ease with which these fluorlonophores were prepared from a common core underscores the utility of conformational restriction as a signaling mechanism. In addition, for the first time, significant changes were observed In biarylpyridlne emission wavelength, allowing ratlometric detection of Hg(II) and Ag(I). Finally, on the basis of computational analyses, beneficial structural modifications were predicted for the next generation of chemosensors.

Multi-functionalized 2,2′:6′,2″-terpyridines

In this contribution, Stille-type cross-coupling procedure is shown to be an easy and universal way to prepare a variety of functionalized terpyridines. They may be functionalized in one step with different substituents at the outer pyridine rings and at

2 Tyrosine kinase mediated signal transduction inhibitors

Disclosed herein are compounds of Formula (), and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, X, X, X, X, X, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.

NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS

The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

NOVEL MACROCYCLIC SULFONDIIMINE COMPOUNDS

The present invention relates to novel macrocyclic sulfondiimine compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).