methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate

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Chemical Name:methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate
CAS No.:1394938-52-3
Molecular Formula:C₃₀H₃₀F₃N₅O₅S₂
Molecular Weight:661.726
Hs Code.:

methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate

Synonyms:methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate

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Chemical Property of methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate

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Technology Process of methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate

There total 13 articles about methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: C₃₂H₃₄F₃N₅O₆S₂

: 1394938-52-3
methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate

Guidance literature:: With trifluoroacetic acid; In water; for 5h;
DOI:10.1002/cmdc.201402424

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1394938-52-3
methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 0.33 h / 0 °C

4.1: 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; 1,2-dimethoxyethane / 4 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 - 0 °C / Inert atmosphere

6.1: pyridinium hydrobromide perbromide / N,N-dimethyl-formamide / 0.83 h / 20 °C / Inert atmosphere

7.1: N,N-dimethyl-formamide; ethanol / 2 h / 60 °C / Inert atmosphere

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 5 h / 20 °C

9.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

10.1: trifluoroacetic acid / water / 5 h

With 4-methyl-morpholine; pyridine; dmap; isopropylmagnesium chloride; pyridinium hydrobromide perbromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: |Grignard Reaction / 3.2: |Grignard Reaction;
DOI:10.1002/cmdc.201402424

Reference yield:

: 1394938-70-5
3-{[(2,5-difluorophenyl)sulfonyl](methoxymethyl)amino}-2-fluorobenzoic acid

: 1394938-52-3
methyl [(2S)-1-({4-[4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridin-2-yl}amino)propan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; 1,2-dimethoxyethane / 4 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 0 °C / Inert atmosphere

3.1: pyridinium hydrobromide perbromide / N,N-dimethyl-formamide / 0.83 h / 20 °C / Inert atmosphere

4.1: N,N-dimethyl-formamide; ethanol / 2 h / 60 °C / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 5 h / 20 °C

6.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

7.1: trifluoroacetic acid / water / 5 h

With 4-methyl-morpholine; dmap; pyridinium hydrobromide perbromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201402424