N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:209960-05-4
Molecular Formula:C₁₈H₉BrF₄N₄O
Molecular Weight:453.193
Hs Code.:

Synonyms:N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 2 articles about N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 367-24-8
4-bromo-2-fluoroaniline

: 209917-93-1
1-(3-cyanophenyl)-3-trifluoromethylpyrazole-5-carboxylic acid

: 209960-05-4
N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 65 ℃; for 18h;
DOI:10.1021/acs.jmedchem.1c00511

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: N-(3-cyanophenyl)-3-trifluoromethyl-pyrazole-5-carboxylic acid chloride

: 209960-05-4
N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With dmap; In dichloromethane; for 18h;

Reference yield: 23.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 209960-05-4
N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

: 335275-89-3
tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate

Guidance literature:: di-tert-butyl dicarbonate; N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol;

With 3-azapentane-1,5-diamine; In methanol;
DOI:10.1021/acs.jmedchem.1c00511