tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate
CAS No.:335275-89-3
Molecular Formula:C₂₃H₂₁BrF₄N₄O₃
Molecular Weight:557.342
Hs Code.:

Synonyms:tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate

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Chemical Property of tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate

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Technology Process of tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate

There total 3 articles about tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 209960-05-4
N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

: 335275-89-3
tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate

Guidance literature:: di-tert-butyl dicarbonate; N-(4-bromo-2-fluorophenyl)-1-(3-cyanophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol;

With 3-azapentane-1,5-diamine; In methanol;
DOI:10.1021/acs.jmedchem.1c00511

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 335275-89-3
tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 65 °C

2: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.1c00511

Reference yield:

: 209917-93-1
1-(3-cyanophenyl)-3-trifluoromethylpyrazole-5-carboxylic acid

: 335275-89-3
tert-butyl 3-(5-(4-bromo-2-fluorophenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 65 °C

2: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.1c00511