4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate

Base Information

Chemical Name:4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate
CAS No.:1023328-42-8
Molecular Formula:C₃₅H₄₂F₃N₃O₄Si
Molecular Weight:653.817
Hs Code.:

4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate

Synonyms:4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate

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Chemical Property of 4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate

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Technology Process of 4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate

There total 1 articles about 4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-85-0
piperazine

: 74124-79-1
di(succinimido) carbonate

: 1023328-41-7
3-[(S)-3-(tert-Butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-4-(2-fluoro-4-hydroxyphenyl)-1-(4-fluorophenyl)azetidin-2-one

: 1023328-42-8
4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate

Guidance literature:: di(succinimido) carbonate; 3-[(S)-3-(tert-Butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-4-(2-fluoro-4-hydroxyphenyl)-1-(4-fluorophenyl)azetidin-2-one; With triethylamine; In acetonitrile; at 20 ℃; for 1.5h;

piperazine; In acetonitrile;

Reference yield:

: 1023328-42-8
4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate

: 1023328-33-7
3-fluoro-4-{1-(4-fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}phenyl piperazine-1-carboxylate

Guidance literature:: 4-[3-[(S)-3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]-3-fluorophenyl piperazine-1-carboxylate; With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 16h;

With ammonia; In tetrahydrofuran; methanol; dichloromethane;