Technology Process of tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethylcarbamate
There total 11 articles about tert-butyl 2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; sodium nitrite;
In
1,4-dioxane; water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: potassium carbonate / acetonitrile / Reflux
2: triethylamine / dichloromethane / 1 h / 0 - 20 °C
3: potassium carbonate; sodium azide / N,N-dimethyl-formamide / 20 - 60 °C
4: triphenylphosphine / tetrahydrofuran / 1 h
5: dichloromethane / 2 h
6: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere
7: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
8: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 1 h / 20 °C
With
hydrogenchloride; potassium phosphate; sodium azide; potassium acetate; potassium carbonate; triethylamine; triphenylphosphine; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / acetonitrile / 5 h / 80 °C
2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C
3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
4: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 1 h / 20 °C
With
hydrogenchloride; potassium phosphate; tin(II) chloride dihdyrate; potassium carbonate; sodium nitrite;
tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine;
In
1,4-dioxane; ethanol; water; acetonitrile;
