Cytisine hydrochloride

Base Information

Chemical Name:Cytisine hydrochloride
CAS No.:6047-01-4
Molecular Formula:C11H14N2O•ClH
Molecular Weight:226.706
Hs Code.:2933599090
European Community (EC) Number:227-940-6
UNII:1ZI8CA9FWW
Mol file:6047-01-4.mol

Synonyms:3-hydroxy-11-norcytisine;citizine;cystisin;cytisine;cytisine dihydrochloride, trihydrate;cytisine hydrochloride;cytisine hydrochloride, hydrate;cytisine tetrahydrochloride, trihydrate;cytiton;Tabex;Tsitizin

Suppliers and Price of Cytisine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-onehydrochloride 95%
10mg
$ 327.00

American Custom Chemicals Corporation
6-AMINOPYRIMIDIN-2(1H)-ONE HYDROCHLORIDE 95.00%
5MG
$ 500.62

Alichem
(1R,5S)-3,4,5,6-Tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-onehydrochloride
10mg
$ 400.00

Total 10 raw suppliers

Chemical Property of Cytisine hydrochloride

Chemical Property:

Melting Point:152-153oC
Boiling Point:218oC at 2 MM HG
PSA：71.77000
LogP:0.73530
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:226.0872908
Heavy Atom Count:15
Complexity:332

Purity/Quality:

98%Min ^*data from raw suppliers

(1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-onehydrochloride 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2CNCC1C3=CC=CC(=O)N3C2.Cl
Isomeric SMILES:C1[C@H]2CNC[C@@H]1C3=CC=CC(=O)N3C2.Cl

Technology Process of Cytisine hydrochloride

There total 3 articles about Cytisine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 109667-42-7
N-benzyl cytisine

: 6047-01-4
(+/-)-cytisine hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol; under 760 Torr;
DOI:10.1039/b405275g

Reference yield:

: 744212-66-6
11-benzyl-7,11-diazatricyclo[7.3.1]trideca-2,4-diene-6,12-dione

: 6047-01-4
(+/-)-cytisine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / BH₃*THF / tetrahydrofuran / 0 - 20 °C

2: 88 percent / H₂; HCl / Pd(OH)2/C / methanol / 760 Torr

With hydrogenchloride; borane-THF; hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1039/b405275g

Reference yield:

: 744212-60-0
1-[(1-benzyl-6-oxopiperidin-3-yl)methyl]-6-bromopyridin-2(1H)-one

: 6047-01-4
(+/-)-cytisine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / KHMDS; (+/-)-BINAP / Pd(OAc)2 / tetrahydrofuran / 70 °C

2: 55 percent / BH₃*THF / tetrahydrofuran / 0 - 20 °C

3: 88 percent / H₂; HCl / Pd(OH)2/C / methanol / 760 Torr

With hydrogenchloride; borane-THF; hydrogen; potassium hexamethylsilazane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1039/b405275g