109667-42-7Relevant articles and documents
Concise synthesis of (±)-cytisine via lithiation of N-Boc-bispidine
Stead, Darren,O'Brien, Peter,Sanderson, Adam J.
, p. 4459 - 4462 (2005)
(Chemical Equation Presented) (±)-Cytisine has been synthesized in 19% overall yield via a six-step approach from commercially available materials. Key features of this new strategy are as follows: (i) initial construction of the bispidine core, (ii) lithiation-transmetalation-allylation of an N-Boc-bispidine, and (iii) a Pd/C-mediated dihydropyridone oxidation-N- debenzylation process.
Synthesis and biological activity of N-benzyl derivatives of cytisine
Rakhimov,Vinogradova,Mirzaev,Vypova,Kazantseva
, p. 462 - 469 (2006)
The reductive alkylation of cytisine by various aromatic aldehydes was studied. Preliminary pharmacological investigations of the synthesized compounds were performed.
Evaluation of sparteine-like chiral diamines in the enantioselective lithiation-electrophilic trapping of an O-alkyl carbamate
Genet, Cedric,McGrath, Matthew J.,O'Brien, Peter
, p. 1376 - 1382 (2007/10/03)
Seven (+)-sparteine-like diamines and (-)-sparteine were evaluated in the diamine-mediated asymmetric lithiation-trapping of an O-alkyl carbamate. The (+)-sparteine-like diamines (≥98: 2 er by chiral shift NMR spectroscopy) were prepared from (-)-cytisine
