(S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

Base Information

Chemical Name:(S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate
CAS No.:1456506-78-7
Molecular Formula:C₁₈H₂₀F₃NO₅S
Molecular Weight:419.422
Hs Code.:

Synonyms:(S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

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Chemical Property of (S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

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Technology Process of (S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

There total 2 articles about (S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1456506-81-2
(S)-5,5-dimethyl-3-(4-oxocyclohexyl)-4-phenyloxazolidin-2-one

: 1456506-78-7
(S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

: 1456506-77-6
(R)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

Guidance literature:: (S)-5,5-dimethyl-3-(4-oxocyclohexyl)-4-phenyloxazolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.833333h;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at 20 ℃; for 16.5h; Overall yield = 71 %; Overall yield = 25 g; Inert atmosphere;

Reference yield:

: 1456516-92-9
(S)-3-(4-hydroxycyclohexyl)-5,5-dimethyl-4-phenyloxazolidin-2-one

: 1456506-78-7
(S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

: 1456506-77-6
(R)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 22.5 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.83 h / -78 °C

2.2: 16.5 h / 20 °C / Inert atmosphere

With Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1456506-78-7
(S)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

: 1456506-77-6
(R)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohex-1-en-1-yltrifluoromethanesulfonate

: 501435-91-2
5-bromo-2-fluoropyridin-3-ylboronic acid

: 1456506-84-5
(S)-3-((R)-4-(5-bromo-2-fluoropyridin-3-yl)cyclohex-3-en-1-yl)-5,5-dimethyl-4-phenyloxazolidin-2-one

: 1456506-85-6
(S)-3-((S)-4-(5-bromo-2-fluoropyridin-3-yl)cyclohex-3-en-1-yl)-5,5-dimethyl-4-phenyloxazolidin-2-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h; Overall yield = 62.1 %; Overall yield = 0.659 g; Inert atmosphere; Sealed tube; Microwave irradiation;