3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole

Base Information

Chemical Name:3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole
CAS No.:123705-27-1
Molecular Formula:C₁₄H₁₅ClN₂O₄
Molecular Weight:310.737
Hs Code.:

Synonyms:3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole

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Chemical Property of 3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole

Chemical Property:

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Technology Process of 3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole

There total 8 articles about 3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 541-41-3
chloroformic acid ethyl ester

: 123705-26-0
3-Methoxy-4-(2-aminophenyl)-5-chloromethylisoxazole

: 123705-27-1
3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole

Guidance literature:: With potassium carbonate; In water; acetone; for 2h; Ambient temperature;

Reference yield:

: 10565-19-2
Ethyl 2-(2-Nitrophenyl)-3-oxobutyrate

: 123705-27-1
3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / 4-toluenesulfonic acid / toluene / 48 h / Heating

2: 66 percent / hydroxylamine hydrochloride, KOH / methanol / 64 h / 4 °C

3: 90 percent / HCl conc. / methanol / 4 h / 70 °C

4: 58 percent / diethyl ether / 1.) 0 deg C, 2.) 2h, rt

5: 70 percent / N-Bromosuccinimide, 2,2'-azobisisobutyronitrile / CCl₄ / 48 h / 80 °C

6: 95 percent / tin chloride dihydrate, conc. HCl / methanol / 2.5 h / 80 °C

7: 90 percent / K₂CO₃ / acetone; H₂O / 2 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tin chloride dihydrate; hydroxylamine hydrochloride; potassium carbonate; toluene-4-sulfonic acid; In methanol; tetrachloromethane; diethyl ether; water; acetone; toluene;

Reference yield:

: 123705-22-6
3-Hydroxy-4-(2-nitrophenyl)-5-methylisoxazole

: 123705-27-1
3-Methoxy-4-(2-N-ethoxycarbonylaminophenyl)-5-chloromethylisoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / diethyl ether / 1.) 0 deg C, 2.) 2h, rt

2: 70 percent / N-Bromosuccinimide, 2,2'-azobisisobutyronitrile / CCl₄ / 48 h / 80 °C

3: 95 percent / tin chloride dihydrate, conc. HCl / methanol / 2.5 h / 80 °C

4: 90 percent / K₂CO₃ / acetone; H₂O / 2 h / Ambient temperature

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tin chloride dihydrate; potassium carbonate; In methanol; tetrachloromethane; diethyl ether; water; acetone;