4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide

Base Information

Chemical Name:4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide
CAS No.:1254969-14-6
Molecular Formula:C₂₀H₂₁N₃O₂S
Molecular Weight:367.472
Hs Code.:

Synonyms:4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide

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Chemical Property of 4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide

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Technology Process of 4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide

There total 3 articles about 4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1254970-05-2
4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid methyl ester

: 75-31-0
isopropylamine

: 1254969-14-6
4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide

Guidance literature:: isopropylamine; With trimethylaluminum; In 1,4-dioxane; toluene; at 20 ℃; for 1h; Inert atmosphere;

4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid methyl ester; In 1,4-dioxane; toluene; at 90 ℃; for 24h;

Reference yield:

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

: 1254969-14-6
4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

1.2: 3 h

2.1: methanol / diethyl ether / 15.5 h

3.1: sulfuric acid / 0.17 h / 90 °C

4.1: trimethylaluminum / 1,4-dioxane; toluene / 1 h / 20 °C / Inert atmosphere

4.2: 24 h / 90 °C

With methanol; n-butyllithium; sulfuric acid; trimethylaluminum; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; toluene;

Reference yield:

: 87967-95-1
5-methyl-3-phenylisoxazole-4-carboxaldehyde

: 1254969-14-6
4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

1.2: 3 h

2.1: methanol / diethyl ether / 15.5 h

3.1: sulfuric acid / 0.17 h / 90 °C

4.1: trimethylaluminum / 1,4-dioxane; toluene / 1 h / 20 °C / Inert atmosphere

4.2: 24 h / 90 °C

With methanol; n-butyllithium; sulfuric acid; trimethylaluminum; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; toluene;