87967-95-1

Usage

Uses

Used in Fragrance Industry:
5-METHYL-3-PHENYL-4-ISOXAZOLECARBALDEHYDE is used as a fragrance ingredient for its distinctive scent, contributing to the formulation of perfumes and personal care products. Its aromatic properties enhance the sensory experience of these products, making it a sought-after component in the fragrance sector.
Used in Pharmaceutical Industry:
As a starting material, 5-METHYL-3-PHENYL-4-ISOXAZOLECARBALDEHYDE is used in the synthesis of various pharmaceuticals. Its chemical structure provides a foundation for creating new medicinal compounds, potentially leading to advancements in healthcare and treatment options.
Used in Agricultural Chemical Industry:
5-METHYL-3-PHENYL-4-ISOXAZOLECARBALDEHYDE is also utilized as a starting material in the development of agricultural chemicals. Its role in creating effective compounds for crop protection and enhancement underscores its importance in the agricultural sector.
Used in Antioxidant Applications:
5-METHYL-3-PHENYL-4-ISOXAZOLECARBALDEHYDE is used as an antioxidant, leveraging its ability to combat oxidative stress. This property makes it a potentially useful ingredient in products that require protection against the damaging effects of free radicals.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, 5-METHYL-3-PHENYL-4-ISOXAZOLECARBALDEHYDE is used as a preservative or treatment agent in various applications to inhibit the growth of microorganisms, ensuring the safety and longevity of products.

InChI:InChI=1/C11H9NO2/c1-8-10(7-13)11(12-14-8)9-5-3-2-4-6-9/h2-7H,1H3

Upstream product

• 408528-01-8 5-methyl-3,N-diphenyl-isoxazole-4-carboximidoyl chloride 
• 18718-79-1 5-methyl-3-phenyl-4-isoxazolylmethanol 
• 873-67-6 benzonitrile oxide 
• 123-73-9 crotonaldehyde 
• 2065-28-3 methyl 5-methyl-3-phenylisoxazole-4-carboxylate 
• 698-16-8 benzohydroximoyl chloride 
• 1136-45-4 5-methyl-3-phenylisoxazol-4-carboxylic acid 
• 1143-82-4 ethyl 5-methyl-3-phenylisoxazole-4-carboxylate 
• 932-90-1 syn-benzaldehyde oxime 
• 123862-91-9 5-methyl-3-phenyl-4-(N-phenylcarbamoyl)isoxazole 

Downstream Products

• 1136-45-4 5-methyl-3-phenylisoxazol-4-carboxylic acid 
• 87967-98-4 NSC 375974 
• 18718-79-1 5-methyl-3-phenyl-4-isoxazolylmethanol 
• 635680-13-6 2-[hydroxy-(5-methyl-3-phenyl-isoxazol-4-yl)-methyl]-acrylic acid methyl ester 
• 675108-96-0 8-bromo-3-(5-methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole 
• 641626-82-6 5-methoxy-2-(5-methyl-3-phenylisoxazol-4-ylmethylene)indan-1-one 
• 1239465-02-1 6-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester 
• 1254966-46-5 4-(2,2-dibromo-vinyl)-5-methyl-3-phenyl-isoxazole 
• 1254970-03-0 2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid ethyl ester 
• 1368806-75-0 tert-butyl 7-(5-methyl-3-phenylisoxazol-4-yl)hept-6-enylcarbamate 
• 1368806-76-1 tert-butyl 7-(5-methyl-3-phenylisoxazol-4-yl)hept-6-enylcarbamate 

Relevant academic research and scientific papers

Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter

A series of dimeric isoxazolyl-1,4-dihydropyridines (IDHPs) were prepared by click chemistry and examined for their ability to bind the multi-drug resistance transporter (MDR-1), a member of the ATP-binding cassette superfamily (ABC). Eight compounds in t

Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

Mercaptoacetamide-based ligands have been designed as a new class of histone deacetylase (HDAC) inhibitors for possible use in the treatment of neurodegenerative diseases. The thiol group of these compounds provides a key binding element for interaction with the catalytic zinc ion, and thus differs from the more typically employed hydroxamic acid based zinc binding groups. Herein we disclose the chemistry and biology of some substituted mercaptoacetamides with the intention of increasing HDAC6 isoform selectivity while maintaining potency similar to their hydroxamic acid analogues. The introduction of a stereocenter α to the thiol group was found to have a considerable impact on HDAC inhibitor potency. These new compounds were also profiled for their therapeutic potential in an invitro model of stress-induced neuronal injury and were found to act as nontoxic neuroprotective agents.

ISOXAZOLES / O-PYRIDINES WITH ETHYL AND ETHENYL LINKER

The present invention is concerned with novel isoxazole-pyridines of formula I wherein R1, R2, R3 and L are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the

ISOXAZOLE-PYRAZOLE DERIVATIVES

The present invention is concerned with isoxazole-pyrazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.

Highly substituted isoxazoles: The Baylis-Hillman reaction of substituted 4-isoxazolecarbaldehydes and attempted cyclization to isoxazole-annulated derivatives

In an attempt to understand the effect of position of the formyl group on the efficiency of Baylis-Hillman reaction within isoxazolecarbaldehydes, the reactions of substituted 4-isoxazolecarbaldehydes to obtain highly substituted isoxazoles are described. Attempts to obtain isoxazole-annulated derivatives from these Baylis-Hillman adducts involving SNR′-SNAr substitution strategy are also described.

Cycloadditions of nitrile oxides to α,β-unsaturated aldehydes. Frontier orbital interactions and secondary orbital interactions at work in determining regiochemistry

The regiochemistry of the cycloadditions of nitrile oxides to crotonaldehyde and cinnamaldehyde has been determined and is dictated by frontier orbital interactions and secondary orbital interactions as well. In cycloadditions to α,β-unsaturated compounds the directive effect of the frontier orbital interactions can be diverted by steric drifts and secondary orbital interactions. (C) 2000 Elsevier Science Ltd.

Eine verbesserte Methode zur Synthese substituierter Isoxazol-4-carbaldehyde

A series of isoxazole-4-carbaldehydes 3 have been readily prepared by simple oxidation of the corresponding isoxazolylalcohols 2 with sodium dichromate in dimethylsulfoxide.

NEUTRAL DICHROMATE OXIDATION. PREPARATION AND UTILITY OF ISOXAZOLE ALDEHYDES

Isoxazole alcohols 1 can be oxidized by potassium dichromate in neutral organic media to give the corresponding aldehydes, 2 without destruction of the isoxazole ring.Isoxazole aldehydes 2 are of utility as starting materials for 4-(4'-isoxazyl)-1,4-dihydropyridines 3.