3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile

Base Information

• Chemical Name: 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile
• CAS No.: 1369695-25-9
• Molecular Formula: C₁₆H₁₀Cl₂N₄
• Molecular Weight: 329.188
• Mol file: 1369695-25-9.mol

Synonyms:3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile

Chemical Property of 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile

There total 5 articles about 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxamide (1369695-23-7) → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile (1369695-25-9)

Guidance literature:

With pyridine; trichlorophosphate; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2012.01.032

Reference yield:

5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester (938182-43-5,595610-40-5) → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile (1369695-25-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / 120 °C / Microwave irradiation

2.1: sodium hydroxide / ethanol / 0.5 h / 110 °C / Microwave irradiation

2.2: pH 4

3.1: trichlorophosphate / 2 h / 120 °C

3.2: 0.5 h / 0 - 20 °C

4.1: pyridine; trichlorophosphate / 2 h / 20 °C

With pyridine; potassium carbonate; sodium hydroxide; trichlorophosphate; In ethanol; acetonitrile;

DOI:10.1016/j.bmc.2012.01.032

Reference yield:

ethyl 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylate → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile (1369695-25-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol / 0.5 h / 110 °C / Microwave irradiation

1.2: pH 4

2.1: trichlorophosphate / 2 h / 120 °C

2.2: 0.5 h / 0 - 20 °C

3.1: pyridine; trichlorophosphate / 2 h / 20 °C

With pyridine; sodium hydroxide; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmc.2012.01.032

upstream raw materials:

5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylic acid

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxamide

2-chloro-5-(chloromethyl)pyridine

Downstream raw materials:

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide