3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide

Base Information

• Chemical Name: 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide
• CAS No.: 1369695-19-1
• Molecular Formula: C₁₆H₁₃Cl₂N₅O
• Molecular Weight: 362.218
• Mol file: 1369695-19-1.mol

Synonyms:3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide

Chemical Property of 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide

There total 6 articles about 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile (1369695-25-9) → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide (1369695-19-1)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In ethanol; at 80 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmc.2012.01.032

Reference yield:

5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester (938182-43-5,595610-40-5) → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide (1369695-19-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / 120 °C / Microwave irradiation

2.1: sodium hydroxide / ethanol / 0.5 h / 110 °C / Microwave irradiation

2.2: pH 4

3.1: trichlorophosphate / 2 h / 120 °C

3.2: 0.5 h / 0 - 20 °C

4.1: pyridine; trichlorophosphate / 2 h / 20 °C

5.1: hydroxylamine hydrochloride; triethylamine / ethanol / 0.5 h / 80 °C / Microwave irradiation

With pyridine; hydroxylamine hydrochloride; potassium carbonate; triethylamine; sodium hydroxide; trichlorophosphate; In ethanol; acetonitrile;

DOI:10.1016/j.bmc.2012.01.032

Reference yield:

ethyl 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylate → 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-N-hydroxy-1H-pyrazole-5-carboximidamide (1369695-19-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol / 0.5 h / 110 °C / Microwave irradiation

1.2: pH 4

2.1: trichlorophosphate / 2 h / 120 °C

2.2: 0.5 h / 0 - 20 °C

3.1: pyridine; trichlorophosphate / 2 h / 20 °C

4.1: hydroxylamine hydrochloride; triethylamine / ethanol / 0.5 h / 80 °C / Microwave irradiation

With pyridine; hydroxylamine hydrochloride; triethylamine; sodium hydroxide; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmc.2012.01.032

upstream raw materials:

5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylic acid

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxamide

3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carbonitrile