Denifanstat

Base Information

Chemical Name:Denifanstat
CAS No.:1399177-37-7
Molecular Formula:C₂₇H₂₉N₅O
Molecular Weight:439.56
Hs Code.:
UNII:4GF95B2LZA
NCI Thesaurus Code:C118285
Pharos Ligand ID:CTZATXJJRMYG
ChEMBL ID:CHEMBL3661754

Synonyms:4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile;TVB-2640

Suppliers and Price of Denifanstat

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
TVB-2640
100 mg
$ 950.00

DC Chemicals
TVB-2640
250 mg
$ 1700.00

ChemScene
FASN-IN-2 98.52%
50mg
$ 1500.00

ChemScene
FASN-IN-2 98.52%
10mg
$ 550.00

ChemScene
FASN-IN-2 98.52%
5mg
$ 350.00

Total 8 raw suppliers

Chemical Property of Denifanstat

Chemical Property:

Boiling Point:708.3±70.0 °C(Predicted)
Density:1.27±0.1 g/cm3(Predicted)
XLogP3:5.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:439.23721057
Heavy Atom Count:33
Complexity:728

Purity/Quality:

99%, ^*data from raw suppliers

TVB-2640 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)C)C5CCC5
Recent ClinicalTrials:Phase 2 Study of TVB-2640 in KRAS Non-Small Cell Lung Carcinomas

Technology Process of Denifanstat

There total 1 articles about Denifanstat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 162997-34-4
4-(piperidin-4-yl)benzonitrile hydrochloride

: 1399181-93-1
4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoic acid

: 1399177-37-7
2

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;