Technology Process of 4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoic acid
There total 8 articles about 4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol; water;
at 50 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 24 h / 65 °C / Inert atmosphere
2: sulfuric acid; N-iodo-succinimide / 2.5 h / 0 - 20 °C
3: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 100 °C / Inert atmosphere
4: O,O-Diethyl hydrogen phosphorodithioate / water / 3 h / 80 °C
5: tetrahydrofuran / 7 h / 20 °C
6: acetic acid / 3 h / 90 °C
7: water; sodium hydroxide / methanol / 6 h / 50 °C
With
N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sulfuric acid; water; acetic acid; O,O-Diethyl hydrogen phosphorodithioate; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetic acid / 3 h / 90 °C
2: water; sodium hydroxide / methanol / 6 h / 50 °C
With
water; acetic acid; sodium hydroxide;
In
methanol;
