2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid

Base Information

Chemical Name:2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid
CAS No.:1239956-80-9
Molecular Formula:C₂₉H₂₆Cl₂F₃N₃O₅S₂
Molecular Weight:688.576
Hs Code.:

Synonyms:2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid

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Chemical Property of 2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid

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Technology Process of 2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid

There total 9 articles about 2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-35-7
Tau

: C₂₇H₂₀Cl₃F₃N₂O₂S

: 1239956-80-9
2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 455-40-3
3,5-difluorobenzoic acid

: 1239956-80-9
2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid; magnesium sulfate / toluene / 20 °C

2: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / 3 h / -78 °C

3: sodium tetrahydroborate / methanol / 0.33 h / 0 °C

4: triethylamine / dichloromethane / 0.5 h / 0 °C

5: potassium carbonate / acetone / 1.25 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

7: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

8: triethylamine / dichloromethane / 0 - 20 °C

With sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; sulfuric acid; magnesium sulfate; potassium carbonate; triethylamine; diisopropylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexanes; dichloromethane; acetone; toluene;

Reference yield:

: 1239964-17-0
tert-butyl 3,5-difluoro-4-(hydroxymethyl)benzoate

: 1239956-80-9
2-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)ethanesulfonic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: potassium carbonate / acetone / 1.25 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C

With oxalyl dichloride; potassium carbonate; triethylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; acetone;