Technology Process of C12H13Cl2N
There total 5 articles about C12H13Cl2N which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
carbonochloridic acid 1-chloro-ethyl ester;
In
toluene;
Cooling with ice;
Reflux;
DOI:10.1021/ml300262e
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium hydroxide; water / methanol / 20 - 30 °C
2: triethylamine; 2-chloro-1-methyl-pyridinium iodide / dichloromethane / 1.5 h / 20 °C
3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 1.5 h / 40 °C / Inert atmosphere
4: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice; Reflux
5: carbonochloridic acid 1-chloro-ethyl ester / toluene / Cooling with ice; Reflux
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; 2-chloro-1-methyl-pyridinium iodide; water; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ml300262e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice; Reflux
2: carbonochloridic acid 1-chloro-ethyl ester / toluene / Cooling with ice; Reflux
With
lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester;
In
tetrahydrofuran; toluene;
DOI:10.1021/ml300262e
