(2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol

Base Information

Chemical Name:(2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol
CAS No.:1238895-00-5
Molecular Formula:C₂₅H₃₇NO₂Si
Molecular Weight:411.66
Hs Code.:

Synonyms:(2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol

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Technology Process of (2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol

There total 1 articles about (2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 74879-43-9,92850-36-7,142292-44-2,139437-46-0
(R)-N-benzylidene-2-hydroxy-1-phenylethylamine

: 91202-71-0,132549-08-7
(Z)-4-bromo-1-(tert-butyldimethylsilyloxy)but-2-ene

: (2R)-2-{[(1S,2R)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol

: 1238895-00-5
(2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol

Guidance literature:: With cerium(III) chloride heptahydrate; zinc; In tetrahydrofuran; at 20 ℃; for 4h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201000255

Reference yield: 73.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1238895-00-5
(2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol

: 1238895-31-2
tert-butyl [(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-enyl]carbamate

Guidance literature:: (2R)-2-{[(1R,2S)-2-[(tert-butyldimethylsilyloxy)methyl]-1-phenylbut-3-en-1-yl]amino}-2-phenylethanol; With methanol; lead(IV) tetraacetate; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

With hydroxylamine hydrochloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201000255