tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate

Base Information

• Chemical Name: tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate
• CAS No.: 352356-41-3
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.45
• Mol file: 352356-41-3.mol

Synonyms:tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate

Chemical Property of tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate

There total 1 articles about tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl bromide (100-39-0) + 2,3,4,5-Tetrahydro-4-[(1,1-dimethylethoxy)-carbonyl]-1H-1,4-benzodiazepine (195983-63-2) → tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate (352356-41-3)

Guidance literature:

2,3,4,5-Tetrahydro-4-[(1,1-dimethylethoxy)-carbonyl]-1H-1,4-benzodiazepine; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

benzyl bromide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1021/acs.jmedchem.6b01356

Reference yield:

tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate (352356-41-3) → 1-benzyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; Cooling with ice;

DOI:10.1021/acs.jmedchem.6b01356

Reference yield:

tert-butyl 1-benzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate (352356-41-3) → N,1-dibenzyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C / Cooling with ice

2: triethylamine / acetonitrile / 18 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; ethanol; acetonitrile;

DOI:10.1021/acs.jmedchem.6b01356

upstream raw materials:

benzyl bromide

2,3,4,5-Tetrahydro-4-[(1,1-dimethylethoxy)-carbonyl]-1H-1,4-benzodiazepine