10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester

Base Information

• Chemical Name: 10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester
• CAS No.: 868132-41-6
• Molecular Formula: C₂₇H₄₂O₃
• Molecular Weight: 414.629
• Mol file: 868132-41-6.mol

Synonyms:10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester

Chemical Property of 10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester

There total 4 articles about 10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

10-(tert-butyldiphenylsilanyloxy)decanoic acid 11-phenyl-undec-10-ynyl ester (868132-36-9) → 10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester (868132-41-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/ja054590i

Reference yield:

10-(tert-butyldiphenylsilanyloxy)decanoic acid (868132-31-4) → 10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester (868132-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / DCC; DMAP / diethyl ether / 16 h / 20 °C

2: 93 percent / TBAF / tetrahydrofuran / 16 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja054590i

Reference yield:

10-(tert-butyldiphenylsilanyloxy)decanoic acid methyl ester (868132-30-3) → 10-hydroxydecanoic acid 11-phenylundec-10-ynyl ester (868132-41-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / aq. Ba(OH)2 / methanol / 2 h / 20 °C

2: 82 percent / DCC; DMAP / diethyl ether / 16 h / 20 °C

3: 93 percent / TBAF / tetrahydrofuran / 16 h / 20 °C

With dmap; barium dihydroxide; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1021/ja054590i

upstream raw materials:

10-(tert-butyldiphenylsilanyloxy)decanoic acid 11-phenyl-undec-10-ynyl ester

10-(tert-butyldiphenylsilanyloxy)decanoic acid methyl ester

10-(tert-butyldiphenylsilanyloxy)decanoic acid

methyl 10-hydroxydecanoate

Downstream raw materials:

10-oxodecanoic acid 11-phenylundec-10-ynyl ester