O₆-(4,5-diacetoxypentyl)-N₂-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Base Information

• Chemical Name: O₆-(4,5-diacetoxypentyl)-N₂-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine
• CAS No.: 1207261-51-5
• Molecular Formula: C₄₈H₅₁N₅O₁₂
• Molecular Weight: 889.959
• Mol file: 1207261-51-5.mol

Synonyms:O₆-(4,5-diacetoxypentyl)-N₂-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Chemical Property of O₆-(4,5-diacetoxypentyl)-N₂-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O₆-(4,5-diacetoxypentyl)-N₂-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

There total 1 articles about O₆-(4,5-diacetoxypentyl)-N₂-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

O6-(4,5-diacetoxypentyl)-N2-phenoxyacetyl-2'-deoxyguanosine (1207261-49-1) + 4,4'-dimethoxytrityl chloride (40615-36-9) → O6-(4,5-diacetoxypentyl)-N2-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (1207261-51-5)

Guidance literature:

With pyridine; dmap; triethylamine; at 60 ℃; for 6h;

DOI:10.1039/c0cc00172d

Reference yield:

O6-(4,5-diacetoxypentyl)-N2-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (1207261-51-5) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → O6-(4,5-diacetoxypentyl)-N2-phenoxyacetyl-3'-O-[(N,N-diisopropylamino)(β-cyanoethoxy)phosphinyl]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (1207261-53-7)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 1.5h;

DOI:10.1039/c0cc00172d

upstream raw materials:

O₆-(4,5-diacetoxypentyl)-N₂-phenoxyacetyl-2'-deoxyguanosine

4,4'-dimethoxytrityl chloride

Downstream raw materials:

O6-(4,5-diacetoxypentyl)-N2-phenoxyacetyl-3'-O-[(N,N-diisopropylamino)(β-cyanoethoxy)phosphinyl]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine