N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide

Base Information

Chemical Name:N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide
CAS No.:1449664-66-7
Molecular Formula:C₂₂H₂₃N₇O
Molecular Weight:401.471
Hs Code.:

Synonyms:N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide

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Chemical Property of N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide

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Technology Process of N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide

There total 12 articles about N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449664-66-7
N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: iron; acetic acid / 1 h / 50 - 80 °C

3.1: 4 h / 100 °C

4.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere

5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0 °C

5.2: 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: triethylamine / N,N-dimethyl-formamide / 26 h / 20 °C

8.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 2 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; iron; caesium carbonate; acetic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4.1: |Buchwald-Hartwig Coupling;

Reference yield:

: 1218791-37-7
2-acetamidopyrimidine-5-boronic acid pinacol ester

: 1449669-97-9
3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenol

: 1449664-66-7
N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; for 2h; Reflux;

Reference yield:

: 929095-68-1
2-bromo-4-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrobenzene

: 1449664-66-7
N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane / 24 h / Reflux

2.1: ammonium chloride; iron / tetrahydrofuran; ethanol; water / 1 h / 90 °C

3.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0 °C

4.2: 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: triethylamine / N,N-dimethyl-formamide / 26 h / 20 °C

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 2 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; iron; ammonium chloride; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: |Buchwald-Hartwig Coupling;