929095-68-1

Upstream product

• 700-36-7 2-bromo-4-fluoronitrobenzene 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 929095-72-7 methyl 5-{[5-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrophenyl]amino}-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate 
• 1449668-92-1 2-ethyl-4-((4-methoxybenzyl)oxy)-1-nitrobenzene 
• 1449669-97-9 3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenol 
• 1449667-57-5 3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenol 
• 1449668-95-4 N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-N-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine 
• 1449668-94-3 N-(2-ethyl-4-((4-methoxybenzyl)oxy)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridin-6-amine 
• 1449668-93-2 2-ethyl-4-((4-methoxybenzyl)oxy)aniline 
• 1449667-73-5 N-(4-(2-(dimethylamino)pyrimidin-5-yl)-2-ethylphenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine 
• 1449664-66-7 N-(5-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)pyrimidin-2-yl)acetamide 
• 1276687-29-6 methyl 3-(benzyloxy)-5-(5-(4-methoxybenzyloxy)-2-nitrophenylamino)thiophene-2-carboxylate 
• 1276687-28-5 methyl (+/-)-5-(5-(4-methoxybenzyloxy)-2-nitrophenylamino)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate 
• 929095-69-2 methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{[5-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrophenyl]amino}-2-thiophenecarboxylate 

Relevant academic research and scientific papers

IMIDAZO [4, 5 -C] PYRIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Wherein R1, L1, R3, R4, Cy, L2 and R5 are as defined herein. Novel imidazolopyridines according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.

Regioselective synthesis of benzimidazole thiophene inhibitors of polo-like kinase 1

A regioselective synthesis of novel 1-(2-thienyl)-benzimidazole inhibitors of polo-like kinase 1 is described. Amination of substituted 2-iodo or -bromo nitrobenzenes with a 2-aminothiophene derivative catalyzed by Pd2dba3 and XANTPH

BENZIMIDAZOLE THIOPHENE COMPOUNDS

The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES

The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.