Technology Process of [5-(3-bromophenyl)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-yl]cyclohexylamine
There total 4 articles about [5-(3-bromophenyl)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-yl]cyclohexylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(3-bromophenyl)-2-hydroxy-2-methylpropane-1-sulfonamide; isothiocyanatocyclohexane;
With
1-methyl-pyrrolidin-2-one; sodium hexamethyldisilazane;
In
water;
for 0.333333h;
With
N-Bromosuccinimide;
In
water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 1.25 h / 20 °C / Cooling with ice
2.1: methyllithium / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere
2.2: 0.17 h
3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
4.1: 1-methyl-pyrrolidin-2-one; sodium hexamethyldisilazane / water / 0.33 h
4.2: 1 h / 20 °C
With
1-methyl-pyrrolidin-2-one; methyllithium; sodium hexamethyldisilazane; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methyllithium / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere
1.2: 0.17 h
2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
3.1: 1-methyl-pyrrolidin-2-one; sodium hexamethyldisilazane / water / 0.33 h
3.2: 1 h / 20 °C
With
1-methyl-pyrrolidin-2-one; methyllithium; sodium hexamethyldisilazane; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
