3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

Base Information

• Chemical Name: 3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate
• CAS No.: 1610449-33-6
• Molecular Formula: C₃₅H₃₃N₇O₅S
• Molecular Weight: 663.757
• Mol file: 1610449-33-6.mol

Synonyms:3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

Chemical Property of 3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

There total 6 articles about 3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea (1562518-34-6) + 3-aminophenyl methanesulfonate (38164-50-0) → 3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate (1610449-33-6)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

Reference yield:

3-nitrophenyl methane sulfonate (19013-29-7) → 3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate (1610449-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 70 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide;

Reference yield:

phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate (1573025-19-0) → 3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate (1610449-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 16 h / Reflux

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 70 °C

With toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

1-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea

3-aminophenyl methanesulfonate

3-nitrophenyl methane sulfonate

phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate