2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid

Base Information

Chemical Name:2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid
CAS No.:134406-14-7
Molecular Formula:C₂₅H₂₇ClN₂O₂
Molecular Weight:422.955
Hs Code.:

Synonyms:2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid

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Chemical Property of 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid

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Technology Process of 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid

There total 9 articles about 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134405-40-6
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid methyl ester

: 134406-14-7
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid

Guidance literature:: With sodium hydroxide; In ethanol; at 25 ℃; for 2h;
DOI:10.1021/jm00099a013

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 134406-14-7
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.33 h / -78 °C

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) NaH / 1.) DME, a) 50 deg C, 15 min, b) 25 deg C, 15 min, 2.) DME, a) 70 deg C, 2 h, b) 25 deg C, 18 h

6: 10percent aq. NaOH / ethanol / 2 h / 25 °C

With manganese(IV) oxide; sodium hydroxide; sodium hydride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00099a013

Reference yield:

: 68283-19-2
2-n-butyl-4-(hydroxymethyl)imidazole

: 134406-14-7
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / 19 h / Ambient temperature

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) NaH / 1.) DME, a) 50 deg C, 15 min, b) 25 deg C, 15 min, 2.) DME, a) 70 deg C, 2 h, b) 25 deg C, 18 h

6: 10percent aq. NaOH / ethanol / 2 h / 25 °C

With manganese(IV) oxide; sodium hydroxide; sodium hydride; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00099a013