68283-19-2

Basic information

• Product Name: 2-Butyl-5-hydroxymethylimidazole
• Synonyms: (2-BUTYL-1H-IMIDAZOL-4-YL)METHANOL;2-BUTYL-5-HYDROXYMETHYL-IMIDAZOLE;2-BUTYL-4-HYDROXYMETHYLIMIDAZOLE;2-N-BUTYL-4-HYDROXYMETHYLIMIDAZOLE;RARECHEM AL BD 1164;2-n-Butyl-5-hydroxymethylimidazole;(2-Butyl-3H-imidazol-4-yl)-methanol;2-N-BUTYL 4-HYDROXY METHYL IMIDAZOLE (IM)
• CAS NO: 68283-19-2
• Molecular Formula: C₈H₁₄N₂O
• Molecular Weight: 154.21
• Product Categories: pharmacetical;Heterocyclic Compounds;Heterocycles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Imidazoles
• Mol File: 68283-19-2.mol
• Article Data: 26

Chemical Properties

• Melting Point: 94 °C
• Boiling Point: 379.2 °C at 760 mmHg
• Flash Point: 183.1 °C
• Appearance: /
• Density: 1.096 g/cm³
• Vapor Pressure: 2E-06mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: 2-8°C
• PKA: 13.81±0.10(Predicted)
• CAS DataBase Reference: 2-Butyl-5-hydroxymethylimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butyl-5-hydroxymethylimidazole(68283-19-2)
• EPA Substance Registry System: 2-Butyl-5-hydroxymethylimidazole(68283-19-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 68283-19-2(Hazardous Substances Data)

Usage

General Description

2-Butyl-5-hydroxymethylimidazole is a chemical compound with the molecular formula C7H12N2O and a molecular weight of 140.18 g/mol. It is a derivative of imidazole and consists of a butyl group and a hydroxymethyl group attached to the imidazole ring. 2-Butyl-5-hydroxymethylimidazole is commonly used as a ligand in coordination chemistry and is a component of various metal complexes. It is also used in the synthesis of pharmaceuticals and agrochemicals. Additionally, 2-Butyl-5-hydroxymethylimidazole has potential application in corrosion inhibition and as a stabilizer in plastic materials.

InChI:InChI=1/C8H14N2O/c1-2-3-4-8-9-5-7(6-11)10-8/h5,11H,2-4,6H2,1H3,(H,9,10)

Upstream product

• 96-26-4 dihydroxyacetone 
• 18257-46-0 pentanamidine hydrochloride 
• 110-62-3 pentanal 
• 997-10-4 3-hydroxy-2-oxo-propionaldehyde 
• 57246-71-6 methyl pentanimidate 
• 62147-49-3 1,3-dihydroxyacetone dimer 
• 110-59-8 pentanonitrile 
• 39739-46-3 methyl pentanimidate hydrochloride 
• 50790-93-7 2-butyl-1H-imidazole 
• 50-00-0 formaldehyd 
• 148990-06-1 ethyl 2-butyl-1H-imidazole-4⁽⁵⁾carboxylate 

Downstream Products

• 134406-26-1 (Z)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(4-methoxy-benzyl)-acrylic acid methyl ester 
• 134405-41-7 (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(4-methoxy-benzyl)-acrylic acid methyl ester 
• 134405-27-9 (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(3,4-dimethoxyphenyl)methyl-2-propenoic acid 
• 134406-27-2 (Z)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-naphthalen-2-ylmethyl-acrylic acid methyl ester 
• 134405-42-8 (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-naphthalen-2-ylmethyl-acrylic acid methyl ester 
• 134406-29-4 (Z)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4-dichloro-benzyl)-acrylic acid methyl ester 
• 134405-43-9 (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4-dichloro-benzyl)-acrylic acid methyl ester 
• 134406-30-7 (Z)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3-phenoxy-benzyl)-acrylic acid methyl ester 
• 134405-44-0 (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3-phenoxy-benzyl)-acrylic acid methyl ester 
• 134405-45-1 (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(2-methyl-benzyl)-acrylic acid methyl ester 
• 134406-32-9 (Z)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(2-methyl-benzyl)-acrylic acid methyl ester 
• 134406-24-9 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(Z)-ylidene]-3-phenyl-butyric acid methyl ester 
• 134405-40-6 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-phenyl-butyric acid methyl ester 
• 133485-48-0 (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-furan-2-ylmethyl-acrylic acid methyl ester 

Relevant articles and documents

Preparation of 2-Substituted 4-Chloro-5-Formylimidazole and 5-Formylimidazole

The invention relates to a preparation process for 2-substituted 5-formylimidazoles, wherein the intermediate high-pressurized synthesis of an 2-substituted 4-hydroxymethylimidazole as known in the art is conveniently avoided, and wherein much higher yields are obtained. Instead, it is proposed to prepare such 2-substituted 5-formylimidazoles via a one-pot synthesis involving 2-substituted 4-chloro-5-formylimidazole, thereby employing an additional hydrodehalogenation step. Moreover, it is found that the yield and purity of 2-substituted 4-chloro-5-formylimidazole itself can be significantly improved using a triflate catalyst in the preparation process.

Medicament

The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for improving cognitive function.

Medicament

The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for primary and secondary prevention of infarction.