N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide

Base Information

Chemical Name:N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide
CAS No.:1454906-62-7
Molecular Formula:C₁₅H₁₉FN₄O₃S
Molecular Weight:354.405
Hs Code.:

Synonyms:N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide

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Chemical Property of N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide

Chemical Property:

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Technology Process of N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide

There total 6 articles about N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454906-61-6
4-fluoromethyl-5-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 1454906-62-7
N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1052114-46-1
tert-butyl ((1R,2S)-3-fluoro-1-hydroxy-1-(4-iodophenyl)propan-2-yl)carbamate

: 1454906-62-7
N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 16 h / 80 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

5: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium acetate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; toluene;

Reference yield:

: 1454906-58-1
(4S,5R)-4-fluoromethyl-5-(4-iodophenyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1454906-62-7
N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 16 h / 80 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium acetate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; toluene;