2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide

Base Information

Chemical Name:2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide
CAS No.:1454904-10-9
Molecular Formula:C₁₇H₁₉Cl₂FN₄O₄S
Molecular Weight:465.333
Hs Code.:

Synonyms:2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide

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Chemical Property of 2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide

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Technology Process of 2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide

There total 7 articles about 2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454906-62-7
N-{5-[4-(2-amino-3-fluoro-1-hydroxypropyl)phenyl]pyrimidin-2-ylmethyl}methanesulfonamide

: 535-15-9
ethyl 1,1-dichloroacetate

: 1454904-10-9
2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 24h;

Reference yield:

: 1052114-46-1
tert-butyl ((1R,2S)-3-fluoro-1-hydroxy-1-(4-iodophenyl)propan-2-yl)carbamate

: 1454904-10-9
2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 16 h / 80 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

5: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7: triethylamine / methanol / 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium acetate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; toluene;

Reference yield:

: 1454906-58-1
(4S,5R)-4-fluoromethyl-5-(4-iodophenyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1454904-10-9
2,2-dichloro-N-(1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)pyrimidin-5-yl]phenyl}ethyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 16 h / 80 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6: triethylamine / methanol / 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium acetate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; toluene;