[¹⁴C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one

Base Information

• Chemical Name: [¹⁴C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one
• CAS No.: 1542204-75-0
• Molecular Formula: C₁₇H₂₁N₅O₃
• Molecular Weight: 345.374

Synonyms:[¹⁴C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one

Chemical Property of [¹⁴C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of [¹⁴C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one

There total 4 articles about [¹⁴C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

[14C]2-chloro-1-ethyl-7-(4-methoxybenzyl)-1H-purin-6(7H)-one (1542204-72-7) + ethanolamine (141-43-5) → [14C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one (1542204-75-0)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 3h; Inert atmosphere;

DOI:10.1002/jlcr.3080

Reference yield:

[14C]ethyl 2-(N'-cyano-N-(4-methoxybenzyl)formimidamido)acetate → [14C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one (1542204-75-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfolane; potassium tert-butylate / 1 h / 90 °C

2: sulfolane; potassium tert-butylate / 120 °C / Inert atmosphere

3: trichlorophosphate / 95 °C / Sealed tube

4: 1-methyl-pyrrolidin-2-one / 3 h / 130 °C / Inert atmosphere

With sulfolane; potassium tert-butylate; trichlorophosphate; In 1-methyl-pyrrolidin-2-one;

DOI:10.1002/jlcr.3080

Reference yield:

[14C]ethyl 4-amino-1-(4-methoxybenzyl)-1H-imidazole-5-carboxylate (1542204-67-0) → [14C]1-ethyl-2-((2-hydroxyethyl)amino)-7-(4-methoxybenzyl)-1H-purin-6(7H)-one (1542204-75-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfolane; potassium tert-butylate / 120 °C / Inert atmosphere

2: trichlorophosphate / 95 °C / Sealed tube

3: 1-methyl-pyrrolidin-2-one / 3 h / 130 °C / Inert atmosphere

With sulfolane; potassium tert-butylate; trichlorophosphate; In 1-methyl-pyrrolidin-2-one;

DOI:10.1002/jlcr.3080

upstream raw materials:

[¹⁴C]ethyl 4-amino-1-(4-methoxybenzyl)-1H-imidazole-5-carboxylate

[¹⁴C]1-ethyl-7-(4-methoxybenzyl)-1H-purine-2,6(3H,7H)-dione

[¹⁴C]2-chloro-1-ethyl-7-(4-methoxybenzyl)-1H-purin-6(7H)-one

ethanolamine

Downstream raw materials:

[¹⁴C]5-ethyl-3-(4-methoxybenzyl)-7,8-dihydro-3H-imidazo[2,1-b]purin-4(5H)-one

[¹⁴C]2-chloro-3-(3-chloro-4-methoxybenzyl)-5-ethyl-7,8-dihydro-3H-imidazo[2,1-b] purin-4(5H)-one

[¹⁴C]3-(3-chloro-4-methoxybenzyl)-5-ethyl-2-((tetrahydro-2H-pyran-4-yl)amino)-7,8-dihydro-3H-imidazo[2,1-b]purin-4(5H)-one

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