4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate

Base Information

Chemical Name:4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate
CAS No.:1246247-80-2
Molecular Formula:C₄₈H₄₉F₇N₄O₇
Molecular Weight:926.928
Hs Code.:

4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate

Synonyms:4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate

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Chemical Property of 4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate

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Technology Process of 4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate

There total 14 articles about 4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1246247-79-9
2-{[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}-N-(4-hydroxybutyl)-N-methylacetamide

: 111616-43-4
4-formylphenyl isocyanate

: 1246247-80-2
4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate

Guidance literature:: In toluene; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

: (2R)-1-amino-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(4-fluorophenyl)butan-2-ol

: 1246247-80-2
4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzene / 4 h / Reflux

2.1: dmap; triethylamine / dichloromethane / 18 h / 20 °C / Cooling with ice

3.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

4.1: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

5.1: sodium hydrogencarbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

6.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Cooling with ice

6.2: Cooling with ice

7.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / Cooling with ice; Inert atmosphere

7.2: 16 h / 20 °C / Cooling with ice; Inert atmosphere

8.1: toluene / 16 h / 110 °C / Inert atmosphere

With dmap; tetrabutyl ammonium fluoride; water; pivaloyl chloride; sodium hydrogencarbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; benzene;

Reference yield:

: 1246246-58-1
(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-5-(4-fluorophenyl)-1,3-oxazolidine

: 1246247-80-2
4-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]butyl(4-formylphenyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

3.1: sodium hydrogencarbonate / acetonitrile / 14 h / Inert atmosphere; Reflux

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: triethylamine; pivaloyl chloride / dichloromethane / 0.25 h / Cooling with ice; Inert atmosphere

5.2: 16 h / 20 °C / Cooling with ice; Inert atmosphere

6.1: toluene / 16 h / 110 °C / Inert atmosphere

With dmap; tetrabutyl ammonium fluoride; water; pivaloyl chloride; sodium hydrogencarbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;