2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate

Base Information

Chemical Name:2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate
CAS No.:1246246-62-7
Molecular Formula:C₂₁H₁₈F₇NO₅S
Molecular Weight:529.432
Hs Code.:

Synonyms:2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate

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Chemical Property of 2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate

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Technology Process of 2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate

There total 4 articles about 2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1246246-61-6
2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethanol

: 124-63-0
methanesulfonyl chloride

: 1246246-62-7
2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 1h; Cooling with ice;

Reference yield:

: 1246246-58-1
(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-5-(4-fluorophenyl)-1,3-oxazolidine

: 1246246-62-7
2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

2: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

With dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: (2R)-1-amino-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(4-fluorophenyl)butan-2-ol

: 1246246-62-7
2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 4 h / Reflux

2: dmap; triethylamine / dichloromethane / 18 h / 20 °C / Cooling with ice

3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

4: dmap; triethylamine / dichloromethane / 1 h / Cooling with ice

With dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; benzene;