pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride

Base Information

Chemical Name:pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride
CAS No.:102284-53-7
Molecular Formula:C₁₆H₁₇F₅N₂O₃*ClH
Molecular Weight:416.776
Hs Code.:

Synonyms:pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride

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Chemical Property of pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride

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Technology Process of pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride

There total 6 articles about pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 102284-45-7
pentafluorophenyl N-<(N-boc-L-prolyl)methyl>-N-isopropylcarbamate

: 102284-53-7
pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride

Guidance literature:: With hydrogenchloride; formic acid; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1021/jm00158a025

Reference yield:

: 36919-02-5
pentafluorophenyl chloroformate

: 102284-53-7
pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Et₃N / tetrahydrofuran / 2 h / 5 °C

2: 80 percent / formic acid, HCl / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; formic acid; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00158a025

Reference yield:

: 102284-41-3
N-boc-L-prolyl chloromethyl ketone

: 102284-53-7
pentafluorophenyl N-(L-prolylmethyl)-N-isopropylcarbamate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / sodium iodide / aq. ethanol / 15 h / 65 °C

2: 80 percent / Et₃N / tetrahydrofuran / 2 h / 5 °C

3: 80 percent / formic acid, HCl / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; formic acid; triethylamine; sodium iodide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00158a025