Z-Lys(Tos)-Lys(Tos)-Tyr-N₂H₃

Base Information

• Chemical Name: Z-Lys(Tos)-Lys(Tos)-Tyr-N₂H₃
• CAS No.: 92398-87-3
• Molecular Formula: C₄₃H₅₅N₇O₁₀S₂
• Molecular Weight: 894.083
• Mol file: 92398-87-3.mol

Synonyms:Z-Lys(Tos)-Lys(Tos)-Tyr-N₂H₃

Chemical Property of Z-Lys(Tos)-Lys(Tos)-Tyr-N₂H₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-Lys(Tos)-Lys(Tos)-Tyr-N₂H₃

There total 5 articles about Z-Lys(Tos)-Lys(Tos)-Tyr-N₂H₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Z-Lys(Tos)-Lys(Tos)-Tyr-OMe (92399-14-9) → Z-Lys(Tos)-Lys(Tos)-Tyr-N2H3 (92398-87-3)

Guidance literature:

With hydrazine hydrate; In methanol;

DOI:10.1021/ja00337a046

Reference yield:

carbobenzyloxy-N-epsilon-tosyl-L-lysine (2362-45-0) → Z-Lys(Tos)-Lys(Tos)-Tyr-N2H3 (92398-87-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / Et₃N, 1-hydroxybenztriazole, DCC / dimethylformamide; tetrahydrofuran

2: H₂, 1 N HCl / Pd / methanol

3: 88 percent / Et₃N, 1-hydroxybenztriazole, DCC / dimethylformamide

4: 98 percent / hydrazine hydrate / methanol

With hydrogenchloride; hydrogen; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja00337a046

Reference yield:

L-tyrosine methyl ester HCl (3417-91-2) → Z-Lys(Tos)-Lys(Tos)-Tyr-N2H3 (92398-87-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / Et₃N, 1-hydroxybenztriazole, DCC / dimethylformamide; tetrahydrofuran

2: H₂, 1 N HCl / Pd / methanol

3: 88 percent / Et₃N, 1-hydroxybenztriazole, DCC / dimethylformamide

4: 98 percent / hydrazine hydrate / methanol

With hydrogenchloride; hydrogen; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja00337a046

upstream raw materials:

Z-Lys(Tos)-Lys(Tos)-Tyr-OMe

carbobenzyloxy-N-epsilon-tosyl-L-lysine

L-tyrosine methyl ester HCl

Z-Lys(Tos)-Tyr-OMe