(S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester

Base Information

Chemical Name:(S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester
CAS No.:126766-63-0
Molecular Formula:C₁₅H₁₆Cl₂N₂O₄
Molecular Weight:359.209
Hs Code.:

Synonyms:(S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester

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Chemical Property of (S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester

There total 6 articles about (S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149715-45-7
(S)-4-(phenylmethyl)-2-piperazinemethanol

: 126766-63-0
(S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / H₂, aq. HCl / 10percent Pd/C / tetrahydrofuran / 760 Torr

2: 83 percent / acetonitrile / 0.5 h / Ambient temperature

3: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH

4: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) N-methylmorpholine / 1.) dichloromethane, -68 deg C, 2.5 h, 2.) dichloromethane, -20 deg C, 45 min

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; oxalyl dichloride; hydrogen; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00067a004

Reference yield:

: 149648-95-3
(R)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

: 126766-63-0
(S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

2: 68 percent / H₂, aq. HCl / 10percent Pd/C / tetrahydrofuran / 760 Torr

3: 83 percent / acetonitrile / 0.5 h / Ambient temperature

4: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH

5: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) N-methylmorpholine / 1.) dichloromethane, -68 deg C, 2.5 h, 2.) dichloromethane, -20 deg C, 45 min

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00067a004

Reference yield:

: 149648-94-2
N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-D-serine methyl ester

: 126766-63-0
(S)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) SOCl₂, 2.) aq. NH₃ / 1.) methanol, RT, 2 h, 2.) methanol

2: 92 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: 68 percent / H₂, aq. HCl / 10percent Pd/C / tetrahydrofuran / 760 Torr

4: 83 percent / acetonitrile / 0.5 h / Ambient temperature

5: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH

6: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) N-methylmorpholine / 1.) dichloromethane, -68 deg C, 2.5 h, 2.) dichloromethane, -20 deg C, 45 min

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00067a004