2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine

Base Information

• Chemical Name: 2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine
• CAS No.: 1345956-23-1
• Molecular Formula: C₁₈H₁₃N₃O₂S
• Molecular Weight: 335.386

Synonyms:2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine

Chemical Property of 2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine

Chemical Property:

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Technology Process of 2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine

There total 2 articles about 2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(2-(4-hydroxyphenyl)pyrido[3,2-d]pyrimidin-7-yl)thiophene-2-carbaldehyde (1345956-22-0) → 2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine (1345956-23-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide; at -10 - 20 ℃;

Reference yield:

7-chloro-2-(4-hydroxyphenyl)-pyrido[3,2-d]pyrimidine (1345955-99-8) + (5‐formylthiophen‐3‐yl)boronic acid (175592-59-3) → 2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine (1345956-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

2: sodium tetrahydroborate / methanol; N,N-dimethyl-formamide / 16 h / -10 - 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2014.04.055

Reference yield: 71.0%

2-(4-hydroxyphenyl)-7-(3-(5-hydroxymethyl)thienyl)-pyrido[3,2-c]pyrimidine (1345956-23-1) + methyl iodide (74-88-4) → 2-(4methoxyphenyl)-7-((5-hydroxymethyl)thiophen-3-yl)-pyrido[3,2-d]pyrimidine (1345956-24-2)

Guidance literature:

With silver(l) oxide; In tetrahydrofuran; at 20 ℃; for 24h;

upstream raw materials:

4-(2-(4-hydroxyphenyl)pyrido[3,2-d]pyrimidin-7-yl)thiophene-2-carbaldehyde

7-chloro-2-(4-hydroxyphenyl)-pyrido[3,2-d]pyrimidine

(5‐formylthiophen‐3‐yl)boronic acid

Downstream raw materials:

2-(4methoxyphenyl)-7-((5-hydroxymethyl)thiophen-3-yl)-pyrido[3,2-d]pyrimidine

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